Journal: BMC Cancer
Article Title: Vincristine impairs musculoskeletal development in pediatric mice
doi: 10.1186/s12885-025-15262-x
Figure Lengend Snippet: Vincristine affects trabecular, cortical bone and increases a plasma marker associated with bone resorption (CTX-1). A Quantification of trabecular bone volume fraction (Tb.BV/TV; %), B trabecular thickness (Tb.Th; μm), C trabecular number (Tb.N; μm), D trabecular spacing (Tb.Sp; μm), E connectivity density (Conn.Dn; 1/mm3), F cortical thickness (Ct.Th: mm), G cortical area (Ct.Ar; mm2), H fraction of cortical bone relative to total bone (Ct.Ar/Tt.Ar; %) in the femur of mice. I resistance to force (Polar MOI; J:mm4). J Plasma C-terminal telopeptide of type I collagen (CTX-1; pg/mL). K Representative 3-D images of trabecular bone and cortical bone. Data reported as means ± SD. Different letters denote significant differences: p <0.05. Control ( n =5); Vincristine ( n =5)
Article Snippet: The levels of circulating C-terminal telopeptide of type I collagen (CTX-1) were measured in the plasma from EDTA-treated blood collected from vehicle- and vincristine-treated mice using a specific ELISA kit (NB030329; Novus Biologicals Mouse CTX-1 ELISA Kit, Centennial, USA) according to the manufacturer’s protocol.
Techniques: Clinical Proteomics, Marker, Control